SigTran is a modeling environment especially designed to enable biological researchers to carry out large scale simulations and analysis of complex signal transduction networks.

SigTran currently supports

• Complete elementary reaction capability up to and including ternary reactions
• Michaelis-Menton kinetics
• Clamping of species copy numbers
• Multistate specification and simulation
• Tagged molecule or reaction tracking
• DAE based kinetic simulations for comparison with stochastic simulations and model debugging
• Ensemble simulation with run time and post run time statistical processing
• Graphical display and plotting of simulation output.

SigTran is freely available for downloading and testing. Questions and comments should be directed to the Modeling Group at Cell Systems Initiative modeling@cellsystems.org.